You can change NUMA settings on a per host or per virtual machine basis in ESXi hosts verion 4.1.x and newer

For memory latency sensitive workloads with low processor utilization or high interthread communication, use hyper-threads with fewer NUMA nodes instead of full physical cores spread over multiple NUMA nodes.

Configure virtual machines to use hyper-threading with NUMA.

VMware ESXi 4.1.x Installable
VMware vSphere ESXi 5.5
VMware vSphere ESXi 5.0
VMware vSphere ESXi 5.1
VMware vSphere ESXi 6.5
VMware vSphere ESXi 6.7
VMware vSphere ESXi 6.0
VMware vSphere ESXi 7.0.x
VMware ESXi 4.1.x Embedded

Perform either of the following tasks:

• Configure one virtual machine to use hyper-threading with NUMA, add numa.vcpu.preferHT=TRUE for per-virtual machine advanced configuration file.
  
  To edit with vSphere Client:
• 1. Right-click on VM
  2. Select Edit Settings
  3. Click the Options tab.
  4. Highlight General under Advanced options and click Configuration Parameters.
      
• Configure all virtual machines to use hyper-threading with NUMA, add numa.PreferHT=1 for per-host advanced configuration file.
  
  To edit from vCenter Server:
• 1. Highlight Host.
  2. Click the Configuration tab.
  3. Under Software, click Advanced Settings.
  4. Highlight Numa and browse to Numa.PreferHT.

Additional Information

For translated versions of this article, see:

• 日本語: VMware ESXi 4.1.x / 5.0.x で NUMA によるハイパースレッドを使用するように仮想マシンを構成する (2102266)
• 简体中文: 在 VMware ESXi 4.1.x/5.0.x 中将虚拟机配置为对 NUMA 使用超线程 (2107738)