An inadvertent change in PDL multipathing behavior in ESXi 6.0 results in alternative working paths for a LUN not being checked if a PDL condition/error is detected. When encountering a PDL condition on the active path, the ESXi host initiates a health check against the remaining paths but does not fail over if another path is responsive/healthy.
The correct response is to failover to one of the healthy working paths. As a result is, the host is no longer able to issue I/O to these LUNs until the ESXi host is rebooted.